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Homeland Nickel combines a consolidated portfolio of nine at-surface nickel laterite projects in Southern Oregon with a strategic portfolio of mining equities, offering investors leveraged exposure to domestic US nickel development alongside balance-sheet flexibility and reduced dilution risk.

Overview

Homeland Nickel (TSXV:SHL,OTC:SRCGF) is a Canadian mineral exploration company focused on critical metals, with a primary emphasis on nickel laterite projects in Southern Oregon, USA. Nickel has been designated a critical mineral by the US government, and Homeland Nickel is advancing assets in what it considers the only region in the United States with the geological scale and characteristics required to support a meaningful domestic nickel supply.

The company has assembled a portfolio of nine nickel laterite projects that were originally identified during exploration campaigns conducted from the 1950s through the 1970s. These deposits occur as at-surface laterite lenses formed by the weathering of ultramafic rocks, enabling the use of surface sampling and auger drilling to rapidly define mineral resources. This geological setting allows Homeland Nickel to advance multiple projects efficiently while managing exploration costs.

In parallel with asset consolidation and exploration, Homeland Nickel maintains a portfolio of mining equities in publicly traded companies. Management views this portfolio as a strategic asset that provides additional financial flexibility and potential non-dilutive funding options, supporting a disciplined capital allocation strategy as the company advances its nickel projects through resource definition and technical studies.

Company Highlights

  • Controls nine nickel laterite projects in Southern Oregon — Cleopatra, Red Flat, Eight Dollar Mountain, Woodcock Mountain, Josephine Creek, Iron Mountain, Peavine Mountain, Rough & Ready and Free & Easy — representing the most comprehensive consolidation of historically identified US nickel laterite occurrences
  • Historic resources at Cleopatra (39.5 Mt @ 0.93 percent nickel) and Red Flat (18.8 Mt @ 0.84 percent nickel) provide an advanced starting point with significant expansion potential
  • At-surface nickel laterite mineralization supports rapid, low-cost exploration and resource definition compared to underground nickel sulfide projects
  • Strategic partnerships with Patriot Nickel (property option) and Brazilian Nickel (ore processing) support advancement toward development while limiting shareholder dilution
  • Maintains a portfolio of publicly traded mining equities, providing financial flexibility and optionality to support exploration and development programs

Key Projects

Cleopatra Project

The Cleopatra project is Homeland Nickel’s flagship asset and hosts a historical mineral resource of 39.5 Mt grading 0.93 percent nickel. Mineralization occurs at surface and has historically only been explored to shallow depths (about 12 feet), leaving the deposit open at depth and along strike.

Location map of the Cleopatra Nickel property

Cleopatra is one of two projects optioned to Patriot Nickel under a staged earn-in agreement that includes cash payments, exploration expenditures and advancement to pre-feasibility. Homeland Nickel remains the operator during the exploration phase, retains a 20 percent interest in the Cleopatra project and receives a 20 percent equity interest in Patriot.

Red Flat Project

The Red Flat project is located approximately 12 kilometres inland from Gold Beach, Oregon, and hosts a historical resource of 18.8 Mt grading 0.84 percent nickel. Historical trenching and drilling indicate thick laterite horizons with consistent nickel grades.

Red Flat is accessible via gravel road.

The project has received a Surface Use Determination from the US Forest Service approving a proposed sonic drilling program, subject to a National Environmental Policy Act review. Homeland Nickel plans to update the historical resource and evaluate potential expansion through additional drilling and sampling.

Eight Dollar Mountain Project

The Eight Dollar Mountain project lies within the same ultramafic geological belt as Cleopatra and Red Flat. Surface sampling has returned nickel values of up to 2.2 percent nickel, highlighting the project’s high-grade potential. The property consists of 115 mining claims covering an area of 2,376 acres.

Eight Dollar Mountain is included in the option agreement with Patriot Nickel, with work planned to support an initial mineral resource estimate.

Woodcock Mountain Project

The Woodcock Mountain project covers more than 900 acres and has been identified by the United States Geological Survey as hosting significant nickel laterite mineralization. Historical work has reported grades up to 1.5 percent nickel over 15 feet and values as high as 2.13 percent nickel along a three-kilometre trend.

The project is located outside withdrawn land areas, and Homeland Nickel plans to advance surface sampling and auger drilling to define an initial mineral resource.

Josephine Creek Project

The Josephine Creek project, adjacent to Woodcock Mountain, was staked based on historic nickel laterite exposures. Sampling completed in 2025 returned an average grade of 0.73 percent nickel, with 10 of 82 samples grading 1 percent nickel or higher. The property consists of 174 lode mining claims covering an area of 1,455 acres.

Josephine Creek was sampled by the company in 2025 with 74 samples over 22 individual mining claims returning an average of 0.75 percent nickel with 10 samples grading over 1 percent nickel. The property benefits from proximity to infrastructure and further work is planned in 2026 to support an initial resource estimate.

Rough and Ready

The most recently acquired property, Rough and Ready, has seen extensive surface sampling, auger hole drilling and pit excavations to expose good grade nickel laterite over a wide area. Homeland Nickel will review the extensive data acquired with this project and will sample all claims for nickel during a summer 2026 exploration program.

Iron Mountain, Peavine Mountain and Free & Easy Projects

Homeland Nickel has also staked nickel laterite claims at Iron Mountain, Peavine Mountain and Free & Easy, expanding its portfolio to a total of eight projects. These earlier-stage assets provide additional pipeline depth and optionality as the company advances its more mature projects.

Mining Equities Portfolio

In addition to its wholly owned exploration assets, Homeland Nickel holds a portfolio of publicly traded mining equities, including positions in Canada Nickel Company, Noble Mineral Exploration, Benton Resources, Vinland Lithium and Magna Terra Minerals. This portfolio provides financial flexibility and potential non-dilutive funding options, supporting the company’s exploration strategy while offering exposure to value creation beyond its own project pipeline.

Management Team

Stephen Balch — President, CEO and Director

Stephen Balch is an Ontario-registered geoscientist with over 40 years of experience in mineral exploration, including nearly three decades focused on nickel. His background spans nickel, copper and platinum-group element exploration across major mining jurisdictions, including experience with Inco Limited, FNX Mining, Noront and Voiseys Bay Nickel. He has more than 20 years of public company leadership experience as a CEO, president, technical consultant and director. In 2001, he joined Aeroquest Limited and helped develop the AeroTEM airborne geophysical system, and in 2019 co-founded Canada Nickel Company, where he currently serves as VP Exploration.

Ashley Nadon — Chief Financial Officer

Ashley Nadon is a chartered professional accountant with a BA in Economics and an MBA. She provides consulting and accounting services to private and public companies as the managing director of a chartered professional accounting firm. Nadon brings experience as a CFO of several reporting issuers and currently serves as CFO for Kermode Resources.

Errol Farr — Corporate Secretary

Errol Farr is a seasoned financial professional with more than 35 years of experience in financial management, reporting, business optimization and strategy development. He previously served as CFO of Anaconda Mining, and currently holds senior executive roles including CFO, COO and corporate secretary of Zonetail, CFO of Big Tree Carbon and CFO/corporate secretary of AFR NuVenture Resources, a mining exploration company with US projects.

Vance White — Director

Vance White has over five decades of experience in guiding mineral exploration companies. He has served as president, CEO and director of Noble Mineral Exploration since 2003 and has held director and officer positions with multiple public companies in the mining sector.

Michael Dehn — Director

Michael Dehn is a partner at Avanti Management and Consulting with more than 21 years in the mining industry. He has served as a director of publicly listed and private junior mining companies and is currently president and CEO of Temas Resources and United Lithium. He has been a director of the company’s predecessor since December 2020.

Birks Bovaird — Director

Birks Bovaird is chair of the board of Energy Fuels, a uranium and vanadium mining and development company, and serves as a director of Noble Mineral Exploration. His career has focused on corporate financial consulting and strategic planning, including serving as vice-president of corporate finance at a major Canadian accounting firm. He holds an ICD.D designation and is a graduate of the Canadian Director Education Program.

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Homeland Nickel (TSXV:SHL,OTC: SRCGF) is a Canada-based mineral exploration company targeting critical metals, with a strategic focus on nickel laterite projects in southern Oregon, USA. Recognized as a critical mineral by the US government, nickel underpins Homeland Nickel’s strategy as the company advances assets in what it views as the only US region with the scale and geology capable of supporting a significant domestic nickel supply.

The company has built a portfolio of nine nickel laterite projects originally identified during exploration programs carried out between the 1950s and 1970s. The deposits occur as near-surface laterite lenses formed through the weathering of ultramafic rocks, allowing for efficient surface sampling and auger drilling to quickly delineate mineral resources. This geological setting enables Homeland Nickel to advance multiple projects in parallel while maintaining a cost-effective exploration approach.

Location map of the Cleopatra Nickel property

Alongside project consolidation and exploration, Homeland Nickel also holds a portfolio of mining equities in publicly listed companies. Management considers this portfolio a strategic asset that enhances financial flexibility and offers potential non-dilutive funding opportunities, supporting a disciplined capital allocation strategy as the company progresses its nickel assets through resource definition and technical evaluation.

Company Highlights

  • Controls nine nickel laterite projects in Southern Oregon — Cleopatra, Red Flat, Eight Dollar Mountain, Woodcock Mountain, Josephine Creek, Iron Mountain, Peavine Mountain, Rough & Ready and Free & Easy — representing the most comprehensive consolidation of historically identified US nickel laterite occurrences
  • Historic resources at Cleopatra (39.5 Mt @ 0.93 percent nickel) and Red Flat (18.8 Mt @ 0.84 percent nickel) provide an advanced starting point with significant expansion potential
  • At-surface nickel laterite mineralization supports rapid, low-cost exploration and resource definition compared to underground nickel sulfide projects
  • Strategic partnerships with Patriot Nickel (property option) and Brazilian Nickel (ore processing) support advancement toward development while limiting shareholder dilution
  • Maintains a portfolio of publicly traded mining equities, providing financial flexibility and optionality to support exploration and development programs

This Homeland Nickel profile is part of a paid investor education campaign.*

Click here to connect with Homeland Nickel (TSXV:SHL) to receive an Investor Presentation

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Co-Listing Expands U.S. Investor Access and Visibility in World’s Largest Aviation and Capital Markets

Syntholene Energy CORP (TSXV: ESAF,OTC:SYNTF) (OTCQB: SYNTF) (FSE: 3DD0) (‘Syntholene’ or the ‘Company’) announces that its common shares have been approved for quotation and have commenced trading on the OTCQB Venture Market in the United States under the trading symbol SYNTF. The OTCQB co-listing is intended to broaden the Company’s U.S. investor audience and increase visibility within the world’s largest aviation fuel, capital markets, and energy infrastructure ecosystem.

The OTCQB Venture Market, operated by OTC Markets Group Inc., is a recognized public market in the United States designed for early-stage and developing companies that meet verified reporting and compliance standards. The Company’s primary listing remains on the TSX Venture Exchange under the symbol ESAF.

‘Establishing a U.S. trading presence on the OTCQB is a strategically important step for Syntholene,’ stated Syntholene CEO Dan Sutton. ‘The United States represents the largest aviation market globally and a core center of capital formation for energy and infrastructure investment. Providing U.S. investors with direct access to our shares aligns our capital markets strategy with the jurisdictions driving both demand growth and project financing for synthetic fuels. We view this co-listing as a natural extension of our TSX Venture Exchange and Frankfurt listings, as well as an important foundation for long-term engagement with U.S. institutional, strategic, and retail investors.’

Syntholene believes the OTCQB quotation enhances the Company’s visibility and accessibility in the United States at a time when policy support for sustainable aviation fuel and synthetic fuels is accelerating. U.S. federal and state initiatives, including tax credits, grant programs, and offtake support mechanisms under the Inflation Reduction Act and related Department of Energy and Department of Transportation programs, are driving increased investment into next-generation fuel production infrastructure.

About Syntholene

Syntholene is actively commercializing its novel Hybrid Thermal Production System for low-cost clean fuel synthesis. The target output is ultrapure synthetic jet fuel, manufactured at 70% lower cost than the nearest competing technology today. The company’s mission is to deliver the world’s first truly high-performance, low-cost, and carbon-neutral synthetic fuel at an industrial scale, unlocking the potential to produce clean synthetic fuel at lower cost than fossil fuels, for the first time.

Syntholene’s power-to-liquid strategy harnesses thermal energy to power proprietary integrations of hydrogen production and fuel synthesis. Syntholene has secured 20MW of dedicated energy to support the Company’s upcoming demonstration facility and commercial scale-up.

Founded by experienced operators across advanced energy infrastructure, nuclear technology, low-emissions steel refining, process engineering, and capital markets, Syntholene aims to be the first team to deliver a scalable modular production platform for cost-competitive synthetic fuel, thus accelerating the commercialization of carbon-neutral eFuels across global markets.

For further information, please contact:
Dan Sutton, CEO
comms@syntholene.com 
www.syntholene.com
+1 608-305-4835

Investor Relations
KIN Communications Inc.
604-684-6730
ESAF@kincommunications.com

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Forward-Looking Statements
This press release contains forward-looking statements within the meaning of applicable securities laws. The use of any of the words ‘expect’, ‘anticipate’, ‘aims’, ‘continue’, ‘estimate’, ‘objective’, ‘may’, ‘will’, ‘project’, ‘should’, ‘believe’, ‘plans’, ‘intends’ and similar expressions are intended to identify forward-looking information or statements. All statements, other than statements of historical fact, including but not limited to statements regarding the development and intended benefits of the Company’s technology, commercial scalability, technical and economic viability, anticipated geothermal power availability, anticipated benefit of eFuel, and future commercial opportunities, are forward-looking statements.

The forward-looking statements and information are based on certain key expectations and assumptions made by the Company, including without limitation the assumption that the Company will be able to execute its business plan, that the eFuel will have its expected benefits, that there will be market adoption, and that the Company will be able to access financing as needed to fund its business plan. Although the Company believes that the expectations and assumptions on which such forward-looking statements and information are based are reasonable, undue reliance should not be placed on the forward-looking statements and information because the Company can give no assurance that they will prove to be correct. Since forward-looking statements and information address future events and conditions, by their very nature, they involve inherent risks and uncertainties.

Actual results could differ materially from those currently anticipated due to a number of factors and risks, including, without limitation, Syntholene’s ability to meet production targets, realize projected economic benefits, overcome technical challenges, secure financing, maintain regulatory compliance, manage geopolitical risks, and successfully negotiate definitive terms. Syntholene does not undertake any obligation to update or revise these forward-looking statements, except as required by applicable securities laws.

Readers are advised to exercise caution and not to place undue reliance on these forward-looking statements.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/282096

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Building on exploration success at flagship Matagami project

Nuvau Minerals Inc. (TSXV: NMC,OTC:NMCPF) is pleased to provide a corporate update, highlighting the success of 2025 exploration programs and plans for 2026. Previous exploration has resulted in significant gold and base metal discoveries and has expanded the Company’s base metal mineralized inventory at its Matagami Project in the Abitibi region of Québec.

‘We went public in late 2024 with a mandate to increase base metal resources, initiate gold-focused exploration that has been overlooked on our large-scale property, and accelerate work toward restarting mining operations,’ said Peter van Alphen, Nuvau’s President and Chief Executive Officer. ‘With extensive existing processing and permitted mining operations, the Matagami Property truly represents a near-term production opportunity with limited start-up capital. We have made significant progress, developing two zones of volcanogenic massive sulphide (VMS) mineralization, discovering a new orogenic gold system at Bracemac, and expanding mineralization at the Bracemac-McLeod Mine. This work sets the groundwork for an updated mineral resource estimate on the property, updated economic studies, and advancing the completion of the earn-in from Glencore.’

Key achievements in 2025

Exploration continued across the property, while also progressing multiple initiatives aimed at advancing the planned restart of production:

  • A sonic drilling program was completed to explore for mineralization in the glacial till, which delivered a significant gold grain anomaly with more than 2,000 gold grains per 10 kg of material, in an underexplored part of the property, supported by a near-contiguous sample with 295 gold grains, in hole PD-23-030s.
  • Caber Complex Base Metal Project – The company completed a successful drilling program that returned numerous high-grade intercepts at the Caber Complex deposit. This work was completed to increase drill density in preparation for the completion of an updated Mineral Resource Estimate (MRE).
  • Renaissance Zone – Following the 2023 new VMS discovery, from the first geophysical target tested by Nuvau to the north of the Caber deposits. Twenty-seven holes were drilled, with 16 holes containing semi-massive to massive sulphide mineralization. Additional VMS mineralization was discovered at the PD1-East target, a nearby geophysical anomaly tested in 2025.
  • McLeod Extension – Seven new intersections from 5,526 metres of drilling in 2024 and 2025, following up on the 2023 program that discovered potential to expand mineralization proximal to existing mine workings, including an impressive intercept of 15.30 metres grading 2.92% copper, 15.32% zinc, 0.39 g/t gold, and 98.16 g/t silver.

A new prospective gold horizon was discovered in 2025, immediately east of the Bracemac Mine within a Tonalite intrusive, where the very first drill hole intersected visible gold in quartz veining that returned 8.87 g/t gold over 1.05 metres, including 16.02 g/t gold over 0.55 (BRCG-25-01). Follow-up drilling confirmed continuity of a broad, near-surface mineralized system within a large-scale target area, not tested in historic programs. Assay results are provided in Table 1 and 2 at the end of the document.

Strategic focus in 2026

The Matagami camp uniquely combines district-scale exploration potential with a near-term production restart opportunity, supported by a large land package, existing mineral endowment, and permitted infrastructure. Figure 1 highlights some of the priority exploration target areas.

Figure 1: Nuvau’s 2026 exploration focus areas for gold and base metals (volcanogenic massive sulfides)

To view an enhanced version of this graphic, please visit:
https://images.newsfilecorp.com/files/11236/282093_dcb70e799442ea69_001full.jpg

The company is preparing for a large-scale exploration program in 2026, continuing to test multiple high-quality gold targets and several promising base metal targets, including the Daniel 25 VMS area and untested geophysical anomalies in the central camp.

Gold exploration will focus on the underexplored area hosting the high-grade gold-in-till anomaly, advancing the Thunder Mine target where historic drilling intersected multiple high-grade zones that remain open, and evaluating the broader prospectivity of the footwall gold occurrence at the Bracemac Mine. All permits have been received for the expected exploration program for 2026.

Nuvau will continue to advance work aimed at updating its Mineral Resource Estimates for the multiple deposits located on the property, targeting upgrades to the Caber Complex, as well as initial mineral resource estimates for Bracemac-McLeod and Renaissance.

Following the resource updates, the company anticipates updating the previously completed PEA to include portions of those additional resources, as well as updating the associated economics and mine plans. Permitting initiatives will also continue to prepare the Matagami Property for the restart of mining operations.

Update on Matagami earn-in

Nuvau continues to advance its earn-in with respect to the Matagami Property. On January 28, 2026, Nuvau, Nuvau Minerals Corp. and Glencore Canada Corporation (‘Glencore’) entered into a second amended and restated earn-in agreement (the ‘Second A&R Earn-In Agreement’), which further amends and restates the terms of the earn-in agreement dated March 25, 2022, as previously amended and restated on June 28, 2024.

As Nuvau has satisfied all work requirements to earn the right to acquire a 100% interest in the Matagami Property, Nuvau has been working closely with Glencore to complete the transfer of Glencore’s interest in the Matagami Property to Nuvau. In order to facilitate such transfer, Nuvau and Glencore have agreed to certain technical amendments in the Second A&R Earn-In Agreement to address, among other things, certain regulatory considerations, the obligations of Nuvau with respect to the replacement of financial assurances, and the transfer of permits and authorizations to Nuvau. In addition, Nuvau also agreed to guarantee certain deferred obligations under the Second A&R Earn-In Agreement, updated to reflect status of Nuvau Minerals Inc. as guarantor of the obligations. Pursuant to the Second A&R Earn-In Agreement, Nuvau must complete the earn-in by no later than February 27, 2026.

For additional information, please refer to the Second A&R Earn-In Agreement, a copy of which will be available on SEDAR+ (www.sedarplus.ca) under Nuvau’s issuer profile.

Table 1: Bracemac gold showing assay intervals

DDH interval* From To Length Gold g/t
BRCG-25-01 255.75 265.00 9.25 1.13
Including 255.75 256.80 1.05 8.87
BRCG-25-02 273.60 274.10 0.50 7.07
BRCG-25-03 187.20 195.40 8.20 0.20
Including 187.20 188.00 0.80 1.37
BRCG-25-04 96.25 96.75 0.50 1.17
BRCG-25-04 196.80 233.40 36.6 0.40
Including 196.80 197.30 0.50 7.61
Including 202.30 202.85 0.55 3.15
Including 228.00 229.00 1.00 4.27
BRCG-25-04 293.70 294.20 0.50 2.23
BRCG-25-05 100.00 100.75 0.75 1.98
BRCG-25-05 394.10 401.30 7.20 0.30
Including 394.10 394.90 0.80 1.35
Including 400.80 401.30 0.50 1.54

 

Intervals conveying more than 1 g/t of gold or more than 5 m of composites > 0.2 g/t gold.
* All lengths are core lengths; true width is unknown.

Table 2: Bracemac gold DDH collar position (NAD83/UTM zone18) and drilling direction

DDH X Y Az. Dip.
BRCG-25-01 307638 5506552 179.1 64.5
BRCG-25-02 307638 5506552 170.9 63.4
BRCG-25-03 307638 5506552 177.6 57.6
BRCG-25-04 307690 5506630 200.5 51.3
BRCG-25-05 307690 5506630 196.6 66.2

 

About Nuvau Minerals Inc.
Nuvau is a Canadian mining company focused on the Abitibi Region of mine-friendly Québec. Nuvau’s principal asset is the Matagami Property that is host to significant existing processing infrastructure and multiple mineral deposits and is being acquired from Glencore.

For further information, please contact:
Nuvau Minerals Inc.
Peter van Alphen
President and CEO
Telephone: 416-525-6023
Email: pvanalphen@nuvauminerals.com

Qualified Person and Quality Assurance
Bastien Fresia P. Geo. (Qc), Technical Services Director of Nuvau and a ‘qualified person’ as is defined by National Instrument 43-101, has verified the scientific and technical data disclosed in this news release, and has otherwise reviewed and approved the scientific and technical information in this news release.

Sonic Core has been quicklogged on drilling site and shipped by truck to IOS facilities in Saguenay for detailed logging and sampling by a qualitifed quartenary geologist. Hole core from selected intervals has been bagged and queued for processing in the same facility, where samples were sifted and gold grain concentrated with a proprietary fluidized bed. Concentrates were then dry sifted at 50 μm, the +50 μm being examined under an optical microscope, while the -50 μm was scanned by an automated electron microscope. Every suspected gold grain has been analyzed by Energy Dispersive X-Ray Spectrometer (EDS), and high magnification back-scattered images have been acquired in order to classify morphology. Quality control is ensured via various mass balance calculations and EDS analysis of all grains of interest, prior to results being cross-examined by experienced geologists. In the course of sifting, an aliquot of the sample has been saved and shipped for analysis to Activation Laboratories in Ancaster, Ontario, for ICP-MS-QQQ ultra-trace analyses after aqua-regia digestion. Quality control has been conducted by a certified chemist and includes approximately 15% blanks, certified reference materials and internal reference materials.

Diamond Drill core samples are sawn by staff technicians in Nuvau’s Matagami’s core shed to create half-core splits. One split is retained in the drill core box for archival purposes with a sample tag affixed at each sample interval, and the other split is placed in a labelled plastic bag along with a corresponding sample number tag and placed in the shipment queue. Quality control samples, including blind certified reference material (‘CRM’), blank material, and core duplicates, are inserted at a frequency of 1 in every 20 samples and sample batches of up to 60 samples were then shipped directly by Nuvau personnel to the ALS Canada Ltd. preparation laboratory in Rouyn-Noranda, Québec. All submitted core samples are crushed in full to 95 % passing less than 2 mm (ALS code CRU-32). A 1000-gram sample was then riffled, split from the crushed material and pulverized to 90 % passing 75 μm (SPL-22 and PUL-32a). Pulps are shipped from the preparation laboratory to ALS Canada Ltd.’s analytical lab in North Vancouver, British Columbia, for assay. Lead, silver, copper and zinc analyses were determined by ore grade four acid digestion with an inductively coupled plasma atomic emission spectroscopy (‘ICP-AES’) or atomic absorption spectroscopy (‘AAS’) finish (ALS codes Pb-OG62, Ag-OG62, Cu-OG62 and ZnOG62), whereas gold was determined by 50 g fire assay analysis with an AAS finish (code Au-AA23).

PhotonAssay analysis (code Au-PA01) is used on the samples from Bracemac Gold. The samples are sent to Val d’Or MSALabs. Up to 1kg per sample is pulverized to 70% passing 2mm (CRU-CPA), encapsulated in 500g capacity separated plastic lids, adapted for the method and identified with barcodes and unique ID numbers. The Gamma Ray-based Photon Assay is directly processed in the MSALabs Val d’Or facilities. As the method is non-destructive, the assays can be reprocessed and are conserved for archive and future use in the plastic lids. For comparison, at the initiation of the drilling campaign, the method was tested against Fire Assays in ALSLabs, a 50 g fire assay analysis returned 15.75 g/t Au, compared to 16.02 g/t Au by PhotonAssay.

Cautionary Statements
This news release contains forward-looking statements and forward-looking information (collectively, ‘forward-looking statements’) within the meaning of applicable securities laws. Any statements that are contained in this news release that are not statements of historical fact may be deemed to be forward-looking statements. Forward-looking statements are often identified by terms such as ‘may’, ‘should’, ‘anticipate’, ‘will’, ‘estimates’, ‘believes’, ‘intends’ ‘expects’ and similar expressions which are intended to identify forward-looking statements. More particularly and without limitation, this news release contains forward-looking statements concerning drill results relating to the Matagami Property, the results of the PEA, the potential of the Matagami Property, the timing and commencement of any production, the restart of the Bracemac-McLeod Mine, the completion of the earn-in of the Matagami Property and the timing and completion of any technical studies, feasibility studies or economic analyses. Forward-looking statements are inherently uncertain, and the actual performance may be affected by a number of material factors, assumptions and expectations, many of which are beyond the control of the Company, including expectations and assumptions concerning the Company and the Matagami Property. Readers are cautioned that assumptions used in the preparation of any forward-looking statements may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. Readers are further cautioned not to place undue reliance on any forward-looking statements, as such information, although considered reasonable by the management of the Company at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated.

The forward-looking statements contained in this news release are made as of the date of this news release, and are expressly qualified by the foregoing cautionary statement. Except as expressly required by securities law, neither the Company nor Nuvau undertakes any obligation to update publicly or to revise any of the included forward-looking statements, whether as a result of new information, future events or otherwise.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this news release. No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/282093

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Global gold demand surged past 5,000 tons in 2025 for the first time on record driven by a historic wave of investment inflows and sustained central bank buying, according to the World Gold Council’s (WGC) latest Gold Demand Trends report.

Total gold demand, including over-the-counter transactions, exceeded the 5,000-ton threshold as investors, institutions, and official buyers responded to geopolitical risk, falling real rates, and growing uncertainty across bond and equity markets.

Combined with a year of relentless price gains, the surge pushed the total value of global gold demand to a record US$555 billion, up 45 percent year-on-year.

Consequently, gold prices themselves rewrote the record books. The LBMA PM gold price set 53 new all-time highs during 2025, with the average price in the fourth quarter climbing to US$4,135 per ounce, up 55 percent from a year earlier.

Investment demand dominates, central banks remain a critical anchor

The WGC reported that investment demand was the primary driver of growth, accounting for the bulk of incremental buying during the year.

Global gold exchange-traded funds recorded net inflows of 801 tons in 2025, the second-strongest annual increase on record, which reversed years of subdued ETF participation.

At the same time, bar and coin demand accelerated sharply. Demand rose to a 12-year high as retail and high-net-worth investors sought safe-haven exposure in the midst of persistent geopolitical tensions and uncertainty around monetary policy trajectories.

That momentum carried into the final months of the year. Total fourth-quarter gold demand reached 1,303 tons, the highest ever recorded for a fourth quarter, further supported by ETF inflows of 175 tons and bar and coin buying of 420 tons.

Meanwhile, central banks continued to provide a firm foundation for demand even as purchases eased modestly from the extraordinary levels of recent years.

According to the report, net official-sector buying reached 863 tons in 2025, remaining historically elevated but below the more than 1,000 tons added in each of the previous three years. In the fourth quarter, buying accelerated with central banks purchasing 230 tons, up 6 percent quarter-on-quarter.

For instance, the National Bank of Poland emerged as the largest buyer for the second consecutive year, adding 102 tons in 2025 and lifting its gold reserves to 550 tons. Gold now accounts for 28 percent of Poland’s total reserves, approaching its revised 30 percent allocation target.

In January, the bank’s governor signaled an intention to increase reserves further to 700 tons, citing national security considerations.

Supply growth muted, technology demand holds steady

On the supply side, the response to soaring prices remained unexpectedly subdued. Total gold supply rose just 1 percent year-on-year to 5,002 tons, the highest level in the WGC’s annual data series dating back to 1970.

Mine production inched up to an estimated 3,672 tons, potentially setting a new record, while recycling increased only 3 percent to 1,404 tons. This was a muted reaction given the 67 percent rise in the US-dollar gold price.

The council explained the weak recycling response reflected the absence of economic distress, expectations of further price appreciation, and structural behaviours in key markets. This included the use of gold as collateral and the prevalence of trade-in transactions rather than outright selling.

Meanwhile, gold demand in the technology sector remained broadly stable at 323 tons for the year, supported by continued growth in artificial-intelligence-related applications.

The AI boom increased demand for high-speed computing and data-center infrastructure. However, the report also noted that rising gold prices continued to push manufacturers toward thrifting, substitution, and research into alternative materials.

From a commodity to a strategic asset

Overall, 2025 marked an evolution of how industry stakeholders view the metal in relation to changing market dynamics.

Randy Smallwood, president and chief executive officer of Wheaton Precious Metals (TSX:WPM,NYSE:WPM) said investors are increasingly recognising gold as a monetary asset rather than a cyclical commodity.

“For the last 40 years, we’ve thought of gold as a commodity,” Smallwood said. “We forgot that it’s a currency, and it is a currency,” said Randy Smallwood, president and chief executive officer of Wheaton Precious Metals, in a fireside chat at the Vancouver Resource Investment Conference (VRIC).

“The mining industry doesn’t have an impact on pricing. Doesn’t have an impact on value. It is a currency. It has been a currency for thousands of years,” he added, further noting that new mine supply adds only less than 2 percent annually to the total stock of gold held globally

Smallwood, as well as the council, expects many of the forces that drove 2025’s record demand to remain in place.

“We still see continued strength and appetite for swapping out US dollars, treasuries, whatever you want to call it, any exposure towards gold,” he said. “And that’s not going away.”

Securities Disclosure: I, Giann Liguid, hold no direct investment interest in any company mentioned in this article.

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Amazon said Wednesday it was slashing another 16,000 jobs across the company in an ongoing bid to restructure the sprawling trillion-dollar firm.

‘The reductions we are making today will impact approximately 16,000 roles across Amazon, and we’re again working hard to support everyone whose role is impacted,’ Beth Galetti, Amazon’s senior vice president of people experience and technology, said in a memo to employees.

‘That starts with offering most US-based employees 90 days to look for a new role internally,’ she said. Amazon will ‘continue hiring and investing in strategic areas and functions that are critical to our future.’

Galetti said the cuts would ‘strengthen our organization by reducing layers, increasing ownership, and removing bureaucracy.’

In October, Amazon cut 14,000 jobs primarily at the corporate level. At the time, Galetti cited artificial intelligence as being the “most transformative technology we’ve seen since the internet.”

Amazon has 1.55 million employees worldwide, the company said in a filing last year.

It said Tuesday that it would close some of its Amazon Go and Amazon Fresh physical stores, planning to convert some into Whole Foods Market stores.

While AI was not explicitly cited in Wednesday’s note to Amazon workers, the cuts come as workers nationwide brace for the impact of artificial intelligence in a sluggish labor market.

Companies have started citing ‘efficiency’ as they pursue the implementation of AI.

On Monday, Goldman Sachs CEO David Solomon said that his firm’s headcount would be ‘more constrained in 2026’ as the company sees ‘opportunities for efficiency and we try to deploy those.’

On Tuesday, Pinterest said it would cut 15% of its workforce as it pivoted ‘resources to AI-focused roles and teams that drive AI adoption and execution.’

Last year, Microsoft said it was eliminating 9,000 jobs to improve efficiency. Target also cut 1,800 corporate jobs to reduce ‘complexity.’ Instagram and Facebook owner Meta Platforms also reduced its workforce by around 600 jobs as it shifted toward artificial intelligence.

At the same time, hiring nationwide is slowing and inflation remains elevated.

After three months of contraction last year, the U.S. economy added only 56,000 jobs in November and just 50,000 in December. Meanwhile, inflation remains at 2.7%, well above the Federal Reserve’s target of 2%.

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Blackrock Silver Corp. (TSXV: BRC,OTC:BKRRF) (OTCQX: BKRRF) (FSE: AHZ0) (the ‘Company’ or ‘Blackrock’) is pleased to announce the appointment of Sean Thompson as Head of Investor Relations for the Company.

Mr. Thompson is a seasoned capital markets professional with over 17 years of experience in the metals and mining sector. He has a proven track record of driving shareholder value through strategic communications and stakeholder relationship management, particularly for high-growth, development-stage companies.

Prior to joining Blackrock, Mr. Thompson held senior Investor Relations roles at several highly successful precious metals developers that were ultimately acquired in significant M&A transactions: Atlantic Gold Corp.: acquired for C$722 million and Kaminak Gold Corp.: acquired for C$520 million.

His excellence in the field has been recognized by the broader investment community. Mr. Thompson was awarded ‘Best IR by a TSX Venture listed Company’ at the IR Magazine Awards Canada 2018 and received a nomination for the same award in 2016.

Most recently, Mr. Thompson served as Vice President, Corporate Development & Investor Relations at Westhaven Gold Corp. During his tenure, he was a key member of the leadership team that successfully transitioned the company from a grassroots discovery through to a positive Preliminary Economic Assessment (PEA).

Andrew Pollard, Blackrock’s President and Chief Executive Officer, commented: ‘With an updated preliminary economic assessment in view, a robust treasury, and permitting initiatives well-underway, Sean is joining the Company at a pivotal time as we seek to broaden our market profile. Sean brings an impressive track-record in broadening investor bases with other highly-followed precious metals developers, and we’re excited to welcome him to the team as we position ourselves as the next American silver developer.’

Mr. Thompson holds an MBA from Dalhousie University, providing him with the analytical depth required to help manage and communicate financial modeling and peer-group valuations across the gold and silver sectors.

In connection with Mr. Thompson’s appointment, the Company has granted him 200,000 stock options of the Company (‘Stock Options‘) pursuant to the Company’s Omnibus Equity Incentive Compensation Plan. Each Stock Option entitles him to purchase one (1) common share of the Company (each, a ‘Common Share‘) at an exercise price per Common Share of $1.53 and will vest as to one-third on each of the first, second and third anniversaries of the date of grant, expiring on January 29, 2031.

About Blackrock Silver Corp.

Backed by gold and silver ounces in the ground, Blackrock is a junior precious metal focused exploration and development company driven to add shareholder value. Anchored by a seasoned Board of Directors, the Company is focused on its 100% controlled Nevada portfolio of properties consisting of low-sulphidation, epithermal gold and silver mineralization located along the established Northern Nevada Rift in north-central Nevada and the Walker Lane trend in western Nevada.

Additional information on Blackrock Silver Corp. can be found on its website at www.blackrocksilver.com and by reviewing its profile on SEDAR+ at www.sedarplus.ca.

Cautionary Note Regarding Forward-Looking Statements and Information

This news release contains ‘forward-looking statements’ and ‘forward-looking information’ (collectively, ‘forward-looking statements‘) within the meaning of Canadian and United States securities legislation, including the United States Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical fact, are forward-looking statements. Forward-looking statements in this news release relate to, among other things: the advancement of the Tonopah West project towards development, including permitting and de-risking initiatives at the Tonopah West project; the intention to complete an updated Preliminary Economic Assessment on the Tonopah West project and the timing of completion thereof; the Company’s intentions to broaden its market profile; and the Company’s positioning as an American silver developer.

These forward-looking statements reflect the Company’s current views with respect to future events and are necessarily based upon a number of assumptions that, while considered reasonable by the Company, are inherently subject to significant operational, business, economic and regulatory uncertainties and contingencies. These assumptions include, among other things: conditions in general economic and financial markets; accuracy of assay results; geological interpretations from drilling results, timing and amount of capital expenditures; performance of available laboratory and other related services; future operating costs; the historical basis for current estimates of potential quantities and grades of target zones; the availability of skilled labour and no labour related disruptions at any of the Company’s operations; no unplanned delays or interruptions in scheduled activities; all necessary permits, licenses and regulatory approvals for operations are received in a timely manner; the ability to secure and maintain title and ownership to properties and the surface rights necessary for operations; and the Company’s ability to comply with environmental, health and safety laws. The foregoing list of assumptions is not exhaustive.

The Company cautions the reader that forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause actual results and developments to differ materially from those expressed or implied by such forward-looking statements contained in this news release and the Company has made assumptions and estimates based on or related to many of these factors. Such factors include, without limitation: the timing and content of work programs; results of exploration activities and development of mineral properties; the interpretation and uncertainties of drilling results and other geological data; receipt, maintenance and security of permits and mineral property titles; environmental and other regulatory risks; project costs overruns or unanticipated costs and expenses; availability of funds; failure to delineate potential quantities and grades of the target zones based on historical data; general market, political, economic and industry conditions; and those factors identified under the caption ‘Risks Factors’ in the Company’s most recent Annual Information Form.

Forward-looking statements are based on the expectations and opinions of the Company’s management on the date the statements are made. The assumptions used in the preparation of such statements, although considered reasonable at the time of preparation, may prove to be imprecise and, as such, readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date the statements were made. The Company undertakes no obligation to update or revise any forward-looking statements included in this news release if these beliefs, estimates and opinions or other circumstances should change, except as otherwise required by applicable law.

For further information, please contact:

Andrew Pollard, President & Chief Executive Officer
Blackrock Silver Corp.
Phone: 604 817-6044
Email: andrew@blackrocksilver.com

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/281989

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Romios Gold Resources Inc. (TSXV: RG,OTC:RMIOF) (OTCID: RMIOF) (FSE: D4R) (‘Romios’ or the ‘Company’) is pleased to announce that, pursuant to special resolutions passed by shareholders on January 16, 2026, and the approval of the TSX Venture Exchange, the Company has consolidated its capital on a ten (10) old for one (1) new basis and changed its name to Oreterra Metals Corp. Effective at the open on Monday, February 2, 2026, the common shares of Oreterra Metals Corp. will commence trading on the TSX Venture Exchange on a consolidated basis under the symbol ‘OTMC’. A new corporate website is accessible effective immediately at www.oreterrametals.com.

Prior to giving effect to the consolidation, the Company had 328,059,969 pre-consolidation shares issued and outstanding, in addition to 39,956,667 warrants and 8.700,000 options outstanding. Following the consolidation, the Company has approximately 32,805,996 post-consolidation shares issued and outstanding. In addition there are 3,995,666 warrants exercisable at $0.50 until between August 15, 2028 and December 27, 2029 (which later expiry date is subject to acceleration) and 870,000 options exercisable at between $0.50 and $0.80 until between April 19, 2026 and September 2, 2027.

No fractional common shares will be issued further to the consolidation. In the event a holder of common shares would otherwise be entitled to receive a fractional common share in connection with the consolidation, the number of common shares to be received by such shareholder will be rounded down to the next whole number and no cash consideration will be paid in respect of fractional shares.

The new CUSIP for the Company’s post-consolidated common shares is 68616A100. A letter of transmittal will be mailed to registered shareholders on January 30, 2026 providing instructions with respect to surrendering share certificates representing pre-consolidation shares in exchange for post-consolidation shares issued as a result of the consolidation. Until surrendered, each certificate representing pre-consolidation shares will be deemed to represent the number of post-consolidation shares the holder will receive as a result of the consolidation. Shareholders who hold their shares in brokerage accounts or in book-entry form are not required to take any action.

About Oreterra Metals Corp.

The commencement of trading as Oreterra Metals Corp. under the new ticker OTMC represents the successful culmination of a months-long effort to restructure the Company. Management took on the task because it believes the Company’s wholly-owned Trek South porphyry copper-gold prospect represents, based upon the high-order, complementary results of the spectrum of geosciences applied to the target area to date, among the finest new targets of its kind in BC’s Golden Triangle. The Company recently released (news, January 22, 2026) a National Instrument 43-101 Technical Report for the Trek property which recommends two initial phases of drilling at Trek South, for targeted execution in the approaching 2026 field season. A copy of the Technical Report is available on the Company’s website at www.oreterrametals.com, and on the Company’s SEDAR+ issuer profile at www.sedarplus.ca.

Additional wholly-owned Company property interests include two former producers in Nevada: the Kinkaid claims in the Walker Lane trend covering numerous shallow Au-Ag-Cu workings over what is believed to be one or more porphyry centres (source: J.Biczok, P.Geo, June 2025, Kinkaid Gold-Copper-Silver Project, www.romios.com), and the Scossa mine property in the Sleeper trend which is a former high-grade gold producer (source: J.Biczok, P.Geo, July 2025, Scossa Historic Gold Mine Property, www.romios.com). The Company also holds a 100% interest in the large Lundmark-Akow Lake Au-Cu property adjacent to the northwest of the Musselwhite Mine in northwestern Ontario, where drilling by the Company has produced highly encouraging, broad VMS-style Au-Cu intersections.

For further information, visit www.romios.com or contact:

Kevin M. Keough 
Chief Executive Officer 
Tel: 613 622-1916 
Email: kkeough@romios.com 
Stephen Burega
President
Tel: 647 515-3734
Email: sburega@romios.com

 

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Cautionary Statement Regarding Forward-Looking Information

This news release includes certain ‘forward-looking statements’ which are not comprised of historical facts. Forward-looking statements include estimates and statements that describe the Company’s future plans, objectives or goals, including words to the effect that the Company or management expects a stated condition or result to occur. Forward-looking statements may be identified by such terms as ‘believes’, ‘anticipates’, ‘expects’, ‘estimates’, ‘may’, ‘could’, ‘would’, ‘will’, or ‘plan’. Since forward-looking statements are based on assumptions and address future events and conditions, by their very nature they involve inherent risks and uncertainties. Although these statements are based on information currently available to the Company, the Company provides no assurance that actual results will meet management’s expectations. Risks, uncertainties and other factors involved with forward-looking information could cause actual events, results, performance, prospects and opportunities to differ materially from those expressed or implied by such forward-looking information. Factors that could cause actual results to differ materially from such forward-looking information include, but are not limited to failure to identify mineral resources, delays in obtaining or failures to obtain required governmental, environmental or other project approvals, political risks, inability to fulfill the duty to accommodate First Nations, uncertainties relating to the availability and costs of financing needed in the future, changes in equity markets, inflation, changes in exchange rates, fluctuations in commodity prices, delays in the development of projects, capital and operating costs varying significantly from estimates and the other risks involved in the mineral exploration and development industry, and those risks set out in the Company’s public documents filed on SEDAR+. Although the Company believes that the assumptions and factors used in preparing the forward-looking information in this news release are reasonable, undue reliance should not be placed on such information, which only applies as of the date of this news release, and no assurance can be given that such events will occur in the disclosed time frames or at all. The Company disclaims any intention or obligation to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, other than as required by law.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/282014

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VANCOUVER, BRITISH COLUMBIA / ACCESS Newswire / January 29, 2026 / CoTec Holdings Corp. (TSX-V:CTH)(OTCQB:CTHCF) (‘CoTec’ or the ‘Company’) is pleased to announce the establishment of a wholly-owned subsidiary, CoTec Copper, to accelerate the Company’s investment activities in copper tailings and sulfide deposits.

Julian Treger, CEO of CoTec commented: ‘The establishment of CoTec Copper demonstrates our commitment to advancing investments in copper tailings and copper sulfide deposits globally. CoTec’s multiple technology investments have reached a readiness level where they can potentially enable asset level investments, consistent with our core strategy. We are focused on opportunities to deploy these technologies to recover the significant economic potential of large historical tailings sites and redundant copper deposits where sulfide resources remain undeveloped. CoTec intends to use CoTec Copper as a vehicle to target ‘brown field’ asset investments in historical Tier 1 copper districts over the coming year in the United States, Australia and Africa with the support of our technology partners and local stakeholders.’

About CoTec Holdings Corp.

CoTec Holdings Corp. (TSX-V:CTH)(OTCQB:CTHCF) is redefining the future of resource extraction and recycling. Focused on rare earth magnets and strategic materials, CoTec integrates breakthrough technologies with strategic assets to unlock secure, sustainable, and low-cost supply chains.

CoTec’s mission is clear: accelerate the energy transition while strengthening strategic critical mineral supply chains for the countries we operate in. By investing in and deploying disruptive technologies, the Company delivers capital-efficient, scalable solutions that transform marginal assets, tailings, waste streams, and recycled products into high-value critical minerals.

From its HyProMag USA magnet recycling joint venture in Texas, to iron tailings reprocessing in Québec, to next-generation copper and iron solutions backed by global majors, CoTec is building a diversified portfolio with long-term growth, rapid cash flow potential, and high barriers to entry. The result is a game-changing platform at the intersection of technology, sustainability, and strategic materials.

For more information, please visit www.cotec.ca

For further information, please contact:

Eugene Hercun, VP Finance, +1 604 537 2413

Forward-Looking Information Cautionary Statement

Statements in this press release regarding the Company and its investments which are not historical facts are ‘forward-looking statements’ that involve risks and uncertainties, including statements relating to management’s expectations with respect to its current and potential future investments, including potential investments in copper tailings and copper sulfide deposits, and the benefits to the Company which may be obtained from such investments. Since forward-looking statements address future events and conditions, by their very nature, they involve inherent risks and uncertainties. Actual results in each case could differ materially from those currently anticipated in such statements. For further details regarding risks and uncertainties facing the Company, please refer to the Company’s public disclosure documents, copies of which may be found under the Company’s SEDAR+ profile at www.sedarplus.ca

Neither TSX-V nor its Regulation Services Provider (as that term is defined in the policies of the TSX-V) accepts responsibility for the adequacy or accuracy of this news release.

SOURCE: CoTec Holdings Corp.

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As massive capital flows into the life science sector, two distinct, and potentially opposing, strategic directions have emerged.

While NVIDIA (NASDAQ:NVDA) is expanding its healthcare presence through a US$1 billion deal with Eli Lilly and Company (NYSE:LLY), Twin Health’s metabolic AI uses digital twins alongside device-driven biometrics to reverse chronic disease, a shift with the potential to render some medications, including high-cost GLP-1s, unnecessary.

This convergence of physical AI and digital twin technology marks a new era where silicon meets biology.

The digital twin: From concept to US$1 billion reality

Dr. Michael Grieves first introduced the conceptual model of digital twins at a Society of Manufacturing Engineers conference in Michigan in 2002. He originally called it the “Information Mirroring Model”.

The phrase was coined by NASA technologist John Vickers in 2010. He was collaborating with Dr. Grieves and suggested the name for a NASA technical roadmap to describe the virtual replicas of spacecraft used for simulation and safety.

NVIDIA CEO Jensen Huang is currently the concept’s most well-known advocate after he used it to describe a cornerstone of NVIDIA’s Omniverse and industrial AI strategy at the GTC 2021 keynote. He later expanded this vision at CES 2026, where he declared that “the future of heavy industries starts as a digital twin.”

In a move that expands digital twins’ use cases, NVIDIA and Eli Lilly recently announced a first-of-its-kind, five-year partnership to build a co-innovation lab in the San Francisco Bay Area. This US$1 billion investment focuses on moving drug discovery away from traditional trial-and-error toward a high-speed engineering model.

Under the terms of the collaboration, the lab will utilize NVIDIA’s Vera Rubin chips, the successor to the Blackwell architecture, to provide the massive computational power required for large-scale biological models.

Researchers will use NVIDIA’s BioNeMo AI platform to simulate vast chemical and biological spaces in silico before a single physical molecule is created in a lab.

The collaboration extends into manufacturing, using NVIDIA Omniverse to create digital twins of production lines. This allows Lilly to stress-test supply chains and optimize the manufacturing of high-demand medications, such as GLP-1s and next-generation weight loss drugs.

Twin Health: Reversing chronic disease with digital twins

While NVIDIA and Lilly focus on creating new drugs, Twin Health is using AI to help patients wean off chronic injections.

Twin Health is a precision health company focused on reversing chronic metabolic diseases, specifically type 2 diabetes and related conditions like obesity and hypertension, using AI and digital twin technology. The company was founded by Jahangir Mohammed, a serial entrepreneur who previously founded Jasper, an Internet of Things (IoT) pioneer, which was later acquired by Cisco.

The core of Twin Health’s whole body digital twin technology is creating a dynamic, virtual map of a patient’s unique metabolism by gathering over 3,000 daily data points, including blood sugar, heart rate, sleep and physical activity.

Users wear continuous glucose monitors and smartwatches at home to capture real-time data, paired with a provided smart scale and blood pressure cuff for daily vitals. AI takes this data to build a digital replica of the user’s body’s unique metabolic responses.

No routine clinic visits are required for data collection, though periodic lab work and tele-coaching support the program. Through a mobile app, the AI provides real-time nudges; for example, it might tell the wearer that a 15-minute walk now will stabilize a blood sugar spike from their lunch.

On January 12, the company rang the Nasdaq opening bell as new clinical and economic data were released that highlighted the platform’s efficacy in high-cost patient populations. Central to this milestone was the Cleveland Clinic-led Randomized Controlled Trial (RCT), originally published in the New England Journal of Medicine Catalyst on August 20, 2025.

The study demonstrated that 71 percent of participants achieved type 2 diabetes reversal, defined as a level of hemoglobin A1C below 6.5 without the use of insulin or other glucose-lowering medications, with the exception of metformin, a low-cost, common first-line drug. Crucially for today’s market, the data showed that 85 percent of users were able to eliminate high-cost GLP-1 medications, such as Ozempic and Wegovy, while maintaining optimal blood sugar levels.

Market analysis: The payer revolt and the shift to value

The GLP-1 drug class rapidly transitioned from niche diabetes medications to multi-billion dollar blockbusters for obesity. From 2018 to 2023, researchers found that spending on GLP-1s in the US rose by more than 500 percent to reach US$71.7 billion. Sales are projected to reach US$100 billion by 2030.

In a fierce race to meet skyrocketing demand that outstripped production capacity, Eli Lilly and its main competitor in this space, Novo Nordisk (NYSE:NVO), committed massive investments. Lilly invested US$9 billion into API production, while Novo Nordisk matched this with a US$11 billion investment in facilities across Denmark and North Carolina.

Now, both companies are chasing affordability via direct-to-consumer deals and 2026 oral pills as payers raise plan costs or restrict access. AON’s Global Medical Trend Rates Report for 2026 projects 9.8 percent hikes in employer plan costs from GLP-1s and utilization surges, as Mercer’s Survey on Health and Benefit Strategies for 2026 shows 77 percent of large employers targeting GLP-1 costs, with coverage growth stalling amid restrictions.

The payer revolt is fueling Twin Health’s rise, marked by its US$53 million August 2025 raise for Fortune 500 expansion. Twin Health’s performance model pays on outcomes, delivering an estimated US$8,000 savings per high-cost member.

Big Pharma is betting on AI not just to sustain blockbuster growth but to reinvent the discovery engine amid exploding development costs. At Davos, Nvidia CEO Jensen Huang illustrated this shift bluntly: “Three years ago, most of their R&D budget…was probably wet labs,” Huang said. “Notice the big AI supercomputer that they’ve invested in, the big AI lab. Increasingly, that R&D budget is going to shift towards AI.”

This comes as the pharmaceutical sector comes under pressure to justify hundreds of billions in R&D spending, where Phase I candidates still face a roughly 90 percent failure rate before approval. Eli Lilly could lower the cost of drug failure by embedding NVIDIA’s Vera Rubin chips into a 24/7 learning loop.

The divergence between NVIDIA’s pharmaceutical supercomputer and Twin Health’s metabolic reversal tech captures 2026’s market trend pivot from AI experimentation to proven ROI. Deloitte’s 2026 US Health Care Outlook emphasizes that the industry is moving away from theoretical models in favor of scaling AI to realize measurable financial impact.

Investor outlook

Payers requiring measurable ROI are pushing healthcare innovators to prove value, whether by improving drug discovery or reversing chronic disease.

This tension shapes investment strategies, too. Paul MacDonald, CIO at Harvest ETFs, welcomes AI’s momentum while highlighting GLP-1’s staying power in the firm’s HHL ETF.

“AI in healthcare is very exciting, and we see practicable applications being deployed across many fields, most notably in the diagnostics areas, but increasingly in biopharma research and medical devices.

“As exciting as technology like wearables and designing more personalized lifestyle plans is, we continue to believe that the broader obesity drug classes and markets will continue to grow significantly in the coming years.

MacDonald points to expanding Medicare access and oral formulations as key drivers, even as payers tighten restrictions.

“The systemic benefits and significant health benefits beyond weight loss from the drugs (are) resulting in expanding adoption, and broader coverage affording larger patient cohorts to access the drugs. Currently, there are pilot plans to expand access for Medicare (enrollees) in the USA later this year, which (will expand) the prescription volume potential significantly.

“In addition to the traditional subcutaneous injection, oral options are increasing in availability, and that not only increases the potential for broader adoption but also improves the overall cost structure and margins for the companies with established production facilities.”

MacDonald’s balanced allocation of AI excitement alongside GLP-1 conviction captures a new reality: in 2026, life sciences investors are navigating a complex landscape defined by more variables than ever before.

Securities Disclosure: I, Meagen Seatter, hold no direct investment interest in any company mentioned in this article.

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